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In another study, semaglutide exhibited greater potency in activating GLP-1R compared to GLP-1, with an EC50 of 6.2 pM for semaglutide vs 16.2 pM for GLP-1 (95) (The variability in EC50 values among different studies for GLP-1 was not uncommon attributable to varying assay conditions)
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FASEB J Maternal LDHB Safeguards Redox Balance and Developmental Competence During Preimplantation Embryo Cleavage
Combined effect is bigger The two pulses stack for a release larger than either alone
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