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1) GLP-1: appetite control + slower digestion GLP-1 activation (the pathway used by semaglutide/Wegovy) helps people feel fuller sooner, reduces appetite, and slows gastric emptying often reducing snacking and lowering overall intake
Practical fat management strategies include: Distribute fat intake throughout the day rather than consuming large amounts in a single meal Prioritise unsaturated fats from sources like olive oil, avocados, nuts, and oily fish over saturated fats from cheese, butter, and processed meats Read nutrition labels to understand the fat content of cheese and other dairy products Consider total meal composition a small amount of cheese combined with vegetables and whole grains is generally better tolerated than cheese-heavy dishes Monitor your individual response and adjust accordingly, as tolerance varies considerably between patients Clinical evidence from the STEP (Semaglutide Treatment Effect in People with obesity) clinical trial programme did not mandate specific dietary fat restrictions, but participants received nutritional counselling emphasising a reduced-calorie diet (approximately 500 kcal deficit)
4e and Supplementary Data 3), just as occurred in Gclc -sufficient MZB (Fig
