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Berberine has the strongest evidence for improving insulin sensitivity and glucose metabolism
For instance, lactylation of K508 on NSUN2, a typical methyltransferase responsible for RNA m 5 C modification, enhances its activity, facilitating GCLC m 5 C methylation and stabilizing GCLC mRNA, which enhances GSH production and reduces oxidative stress, thereby promoting gastric cancer cell survival
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