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Providers assess liver and kidney function, personal or family history of medullary thyroid carcinoma, and multiple endocrine neoplasia syndrome before recommending maintenance dosing at any level
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While GLP-1 receptor agonists have been shown to influence gut microbiota composition, evidence linking microbiota characteristics to susceptibility to these adverse events remains limited
In obesity, NNMT activity is unusually high in fat cells, which means a lot of nicotinamide gets thrown out before it can be turned into NAD+
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