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Administration of PLX3397 to mice For pharmacological ablation of microglia, PLX3397 was administrated to mice by supplementation (290 mg/kg of PLX3397 (#C-1271

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Insulin primarily enters the brain via selective, saturable transport across the blood-brain barrier (BBB) 373,374,375 Peripherally produced insulin can also be actively transported into the brain via an endocytic-exocytic mechanism