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7b, c), consistent with the observations in our cell culture studies
These two characteristics make it inherently unsuitable for standard topical delivery: it degrades before it absorbs, and it repels the lipid-rich skin barrier
J Biol Chem 281:1742017431 Michelet F, Gueguen R, Leroy P, Wellman M, Nicolas A, Siest G (1995) Blood and plasma glutathione measured in healthy subjects by HPLC: relation to sex, aging, biological variables, and life habits
The dose is then titrated upwards (typically by 24 units every 37 days) based on fasting glucose measurements, aiming for individualised target levels, commonly 57 mmol/L upon waking, as recommended by NICE
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