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At week 8, arginine and proline, glutamate, aspartate, glycine and serine, phenylalanine and tyrosine metabolisms, urea cycle, ammonia recycling, purine, biotin and phenylacetate metabolisms and phosphatidylethanolamine biosynthesis pathways were significantly altered in ALS compared to control cells (Fig
However, the increase in mGluRs-dependent signaling in the mouse model of FXS was not confirmed in human-based models, and clinical trials with mGluR inhibitors failed to produce a therapeutic effect in FXS patients [331]
Calapre L, Gray ES, Ziman M (2013) Heat stress: a risk factor for skin carcinogenesis
Alzheimers Dement 15 , e12404 (2023)
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