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Other gut hormones, such as gastrin, secretin, cholecystokinin, vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP), stimulate insulin secretion at supraphysiological concentrations
Some potential concerns with long-term use of synthetic drugs include: Digestive discomfort (nausea, bloating, diarrhea) Possible nutrient absorption issues over time The need for ongoing injections or high-cost prescriptions Unknown effects from long-term artificial hormone stimulation Natural herbs and whole-food extracts work differentlythey support the bodys own GLP-1 production and related digestive functions rather than replacing or overriding them
Since substrate availability significantly influences respiratory quotient and fat oxidation rates, variations in macronutrient intake may have confounding effects that influence individual responses to L-carnitine supplementation
In Foyes Principles of Medicinal Chemistry
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