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One study reported increased serum levels of chromogranin A in a mixed population of individuals, some of which had asthma [218]
Therefore, imbalance in ER homeostasis influenced by Sel1L may be one of the major molecular links towards increased white matter injury and exacerbated neurodegeneration in CKD-stroke complex
Additionally, Glutathione supports liver function and the immune system, boosting the body's ability to fight off infections and maintain optimal health
Given the unique risk of SAEs due to the potential for increased incidence of COVID-19 over the study period, we will also perform a sensitivity analysis where COVID-19 related SAEs will be excluded from the analysis
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