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It's something which Ive taken for a few years now as i first came across it thanks to an article from jim stoppanni who does have his critics but he does have some good research papers that he has published too

There is also a possibility that the included studies reporting null or negative associations may be underrepresented in the published literature, leading to an overestimation of the observed association between GLP-1 RAs and CRC susceptibility

In addition, copper is involved in producing melanin

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