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Please refer to the full 2020 ADA Standards of Care for additional details and recommendations regarding intensification of therapy beyond dual antihyperglycemic therapy

Fragmentation using ETD of a proteolytic peptide from exendin-4 [9-39] provided single amino acid resolution HDX at the binding site and indicated weaker thermodynamic stability at the hydrogen bond network in-between the two peptide ligand -helices

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