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These findings led to changes in clinical practice guidelines modern diabetes guidelines recommend GLP-1 agonists (or related drugs) for patients with type 2 diabetes who have cardiovascular risk, and even suggest using a GLP-1 RA prior to insulin in many cases due to their multiple benefits and weight loss advantage ( [10] ) ( [11] )

doi:10.1021/acs.jafc.1c03937

Alternately, incensing number of evidences have confirmed or validated the formation of selenylsulfide (-Se-S-) intermediate and the involvement of thioldisulfide exchange during the GPx cycle [17,18,19]

Tirzepatide is a dual GLP-1/GIP receptor agonist