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To increase the retention duration in the lungs and allow them to pass through the mucus layer, nanoparticles can be made smaller, more electrically neutral, contain compounds that are specifically targeted, have a high encapsulation efficiency, and be less poisonous
However, this association was not observed at the 50 mg dose, and the analysis was based on only two trials with limited sample sizes
It has been investigated for its involvement in angiogenic signaling , where it is referenced in the literature as a modulator of vascular growth factor pathways
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