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The semaglutide weight management drug market widened its clinical reach again when the FDA approved Rybelsus in October 2025 for MACE risk reduction in adults with type 2 diabetes and established cardiovascular disease, and when Wegovys label was updated in August 2025 to include noncirrhotic MASH with moderate-to-advanced fibrosis

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Our data also suggest that Sp, in combination increases the therapeutic potency of L-DOPA by mitigating its chronic toxicity