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Many automatically think that if you have an MTHFR defect, then you need the B12 form, methylcobalamin, but this is simply NOT true

However, the convenience of a single morning dose means most researchers prefer once-daily administration, and the clinical data supporting split dosing specifically for AOD 9604 is limited

They sit near the top of the evidence hierarchy, just below meta-analyses (which combine multiple RCTs)

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