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In this study, the high molecular weight HA used in combination with AOD9604 may have further supported chondrocyte survival and matrix synthesis, contributing to the observed improvements in cartilage morphology and function
An analysis of the mechanism reveals that the nanoparticles facilitate the oxidation of GSH into GSSG, leading to disruptions in redox balance and the antioxidant defense system and therefore accumulation of ROS and lipid peroxides
PMID 22900535
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