Berberine is an alkaloid found in the roots, bark, and other structures of many plants, including the Oregon grape ( Mahonia aquifolium ), goldenseal ( Hydrastis canadensis ), Indian barberry ( Berberis aristata ), and European barberry ( Berberis vulgaris )
By regulating the behavior and number of white blood cells, it can reverse the suppression of the immune system caused by chronic infections such as mononucleosis, hepatitis, herpes, and Lyme disease
A GLP-1R agonist (liraglutide) increased endothelial nitric oxide synthase phosphorylation and nitric oxide (NO) production by the 5-AMP-activated protein kinase (AMPK)-dependent pathway and subsequent NO production in cultured HCAEC [56],[57]
I'll still take it every once in a great while, but the reason I stopped taking it is that I noticed that it made the sleep in the early part of my night very, very deep, very robust, but then I would wake up wide awake or I would sleep till morning