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Whereas central nervous system (CNS) effects are determined by BBB penetration, ocular efficacy is governed by the traversal of the BRB

Table 11: Results at Week 26 in a Trial Comparing TRESIBA to Insulin Glargine U -100 in Adult Patients with Type 2 Diabetes Mellitus on OAD(s)* Study G TRESIBA Administered at the Same Time Each Day or Any Time Each Day as an Add on to One and up to Three of the Following Oral Agents Metformin, Sulfonylurea or Glinides or Pioglitazone in Adult Patients The efficacy of TRESIBA was evaluated in a 26 week randomized, open label, multicenter trial in 687 patients with type 2 diabetes mellitus inadequately controlled on basal insulin alone, oral antidiabetic agents (OADs) alone or both basal insulin and OAD

3 CV death was the first confirmatory secondary endpoint in the testing hierarchy and superiority was not confirmed

These findings could suggest that the effect of liraglutide on hyperandrogenism does not depend exclusively on weight loss, it can also occur at low doses, and that there is probably a synergistic action with metformin