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Despite the added advantages of the freeze-drying method, there are a few disadvantages associated with it such as membrane integrity may be lost, encapsulated substances might leak out from the vesicle and vesicle size might decrease [163]
The synthetic peptide FOX04-DRI selectively disrupts this interaction, thereby restoring the apoptotic activity of p53 and leading to the elimination of senescent cells

Brighten: Wigovi, Monjoro, what they are and what they do in the body
