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[1] [3] Patients with dietary deficiency and intact absorption may require less frequent injections or may be suitable for high-dose oral supplementation instead (typically 50-150 micrograms of cyanocobalamin daily between meals)
This increase in cAMP may activate protein kinase A (PKA), which then appears to phosphorylate hormone-sensitive lipase (HSL) on specific serine sites
.Li, H., Toh, P
The most common vitamin B12 deficiency symptoms are: Fatigue Weakness Loss of appetite Weight loss Numbness and tingling in the hands and feet Soreness of the mouth or tongue A pale yellow tinge to your skin Difficulty maintaining balance Disturbed vision Depression Confusion Poor short-term memory A severe vitamin B12 deficiency can cause megaloblastic anemia, also known as vitamin B12 deficiency anemia, where red blood cells are not produced properly and are larger than normal
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