Barrier methods, like condoms, are advised for 4 weeks after starting or increasing the dose, or a non-oral birth control could be used, such as the IUD, vaginal ring, or hormonal implant (6)
Dietary LC supplementation downregulated mRNA expression relative to FA synthesis, reduced liver lipid and relieved liver damage through regulating -oxidation and biogenesis of mitochondria and peroxisomes, as well as the ER stress pathway in fish fed with HFD
Maintains glutathione reserves, which is important for healthy brain function
However, it is encouraging that preclinical and early human studies suggest that GLP-1 agonism appears broadly protective: indeed clinical trials of these agents are being initiated in cardiovascular disease (SELECT and SOUL trials, see below), NASH, and neurodegeneration (Alzheimers and Parkinsons)