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cardiovascular reactions such as hypotension and palpitations occur less frequently but mandate monitoring when large intravenous boluses ( 50 mg) are delivered over 65 years, and paradoxical agitation, hallucinations, or seizures in children, underscoring the need for individualized risk-benefit assessment

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Individuals with a personal or family history of thyroid tumours should be aware that, in common with other GLP-1 receptor agonists, retatrutide's GLP-1 activity may carry a theoretical thyroid risk

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