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Diabetes Care 39 , 222230 (2016) L.A

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Evidence given to the Nice committee from clinical trials showed tirzepatide at any dose resulted in better glucose control and weight loss compared with semaglutide or insulin therapy

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Yet, GLP-1 (when tested at non-physiological nanomolar levels) robustly inhibited glucagon secretion in isolated islets by mechanisms that cannot be accounted for by paracrine signals (5, 6)

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Gastroenterology 141 , 21662175 e2167 (2011)

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