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Ethics statement The animal studies were approved by the experimental protocols were approved by the Animal Welfare Ethics Committee of Zunyi Medical University (Approval No: ZHSC-2-[2024]023)

However, its important to note that the use of Melanotan 2 is not approved by regulatory bodies such as the drug administration agency or the FDA for these purposes, and potential side effects and long-term safety considerations should be carefully considered before use

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Detailed biological characteristics of GLP-1 and proposed modes of action of GLP-1RAs on the metabolic and CV systems have been investigated in preclinical and clinical studies and summarized elsewhere [7,8,9,10,11,12]