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This is particularly appealing to men over 30 who find it increasingly difficult to achieve muscle gain and maintain physical composition

But more research is needed

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Abbreviations 2-DG: 2-Deoxy-D-glucose ADP: adenosine Diphosphate AML: acute myeloid leukemia ATP: adenosine triphosphate AUL: area per Unit of Length Bcl-xL: B-cell lymphoma-extra large BLI: bioluminescence imaging BSO: buthionine sulfoximine BUN: blood urea nitrogen CML: chronic myeloid leukemia CRc: composite complete remission CREA: creatinine DCFDA: 5-(and-6)-Carboxy-2',7'-Dichlorofluorescein Diacetate DNA: deoxyribonucleic acid DRP1: dynamin-related protein 1 DSB: DNA double-strand break ECL: enhanced luminol-based chemiluminescent ELN: European LeukemiaNet FAB: French-American-British FACS: fluorescence-activated cell sorting FBS: fetal Bovine Serum FCCP: carbonyl cyanide-4-(trifluoromethoxy) phenylhydrazone FIS1: mitochondrial fission protein FLT3: Fms-like tyrosine kinase GDP: guanosine diphosphate GLS2: glutaminase 2 GLUT1: glucose transporter 1 GLUT4: glucose transporter 4 GOT: glutamic-oxaloacetic transaminase GPx: glutathione peroxidase family GR: GSSG reductase GSH: glutathione GSSG: Oxidized GSH GTP: glutamic pyruvic transaminase i.p.: intraperitoneal IHC: Immunohistochemistry ITD: internal tandem duplication KRAS: Kirsten rat sarcoma viral oncogene homolog Mff: mitochondrial fission factor MFI: median fluorescence intensity MFN1: Mitofusin 1 MFN2: Mitofusin 2 MMP: Mitochondrial membrane potential MOMP: mitochondrial outer membrane permeabilization mtETC: mitochondrial electron transport chain NAC: N-acetyl-L-cysteine NAD + : Nicotinamide adenine dinucleotide NADH: Reduced NAD NADPH: nicotinamide adenine dinucleotide phosphate NOD-SCID: nonobese diabetic/severe combined immunodeficiency NSG: NOD-SCID gamma OCR: oxygen consumption rate OMM: Outer mitochondrial membrane OPA1: Optic Atrophy 1 OXPHOS: oxidative phosphorylation PARP1: poly(ADP-ribose) polymerase 1 PDB: protein data bank PER: proton efflux rate PRDXs: peroxiredoxins PUMA: p53 up-regulated modulator of apoptosis PVDF: Polyvinylidene fluoride RNA: Ribonucleic acid ROS: reactive oxygen species RPMI 1640: Roswell Park Memorial Institute SCO2: cytochrome c oxidase 2 SOD: superoxide dismutase TCA: tricarboxylic acid TEM: transmission electron microscopy TIGAR: TP53-induced glycolysis and apoptosis regulator TME: tumor microenvironment TMQ: tetrahydrobenzimidazole TP53: transformation-related protein 53 Z-VAD-FMK: carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone H2AX: -phosphorylated form of histone H2AX References Dohner H, Estey EH, Amadori S, Appelbaum FR, Buchner T, Burnett AK, Dombret H, Fenaux P, Grimwade D, Larson RA, et al