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The compounds operate through distinct, non-overlapping mechanisms (GLP-1/GIP receptor agonism versus NNMT enzyme inhibition) with no documented receptor competition or adverse pharmacokinetic interactions
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Discussion Our concept, which we verified in several previous paper [24, 32, 33, 42], is that if we mimic the specific expression pattern of nutrient transporters at the BBB with a combination of two or three different ligands a more specific targeting of nanoparticles across the BBB can be achieved
They suggest a potential new way to target the disease
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