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This mitochondrial failure is the direct biochemical driver of the profound, debilitating fatigue and post-exertional malaise (PEM) that patients experience after even minor physical or cognitive exertion
What is clearly illegal: marketing them for human use, making medical claims, or selling them as medicine
This makes it particularly valuable in the later stages of a Retatrutide protocol after significant weight has been lost
Several studies have shown that SDH-deficient cells exhibit increased tumorigenesis and that this increase is reversed by the addition of -KG, supporting the idea that succinate accumulation contributes to tumorigenesis through epigenetic modification 100
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