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Previously described cardiovascular effects of GLP-1 RAs are primarily indirect and include enhanced endothelial function and myocardial metabolism, natriuresis and anti-inflammatory and blood pressure-lowering effects

Similarly, the type of cancer cells used to induce tumor formation, whether primary cells derived directly from patient tissues or cultured cell lines, can have profound impacts on the experimental results

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Statistical analysis Graphical presentations, calculations and statistical analyses were carried out with GraphPad Prism software (San Diego, CA, USA)