what to expect with first dose of tirzepatide Expect: Weight Loss in the Week Can I take tirzepatide 2

Higher doses and longer duration of GLP-1 RAs treatment were also associated with increased risk of gallbladder or biliary diseases, although the association was not statistically significant

These include: Nausea (most frequent, affecting up to 20% of patients) Diarrhoea Vomiting Abdominal pain or discomfort Decreased appetite Constipation Dyspepsia (indigestion) For individuals who have undergone cholecystectomy, digestive symptoms may be experienced differently or potentially overlap with post-cholecystectomy digestive changes

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Application of exendin-4 depolarizes the membrane potential and increases the spontaneous discharge rate of orexinergic neurons in the lateral hypothalamus (Acuna-Goycolea and van den Pol, 2004)