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For many people, their body-fat-to-muscle ratio usually improves, as the drug helps them lose body fat without too much muscle

Refined carbohydrates blunt insulin sensitivity improvements

SOLOIST-WHF ( Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure ) evidenced that sotagliflozin initiated before or shortly after discharged was associated with reduce risk for mortality from cardiovascular deaths and urgent visits for HF in comparison with placebo (62)

Anyone participating in a clinical trial who experiences persistent or severe gastrointestinal symptoms, unexplained abdominal pain (which may indicate pancreatitis or gallbladder disease), signs of dehydration, or other concerning symptoms should contact their supervising healthcare team promptly