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Secondary outcomes The secondary outcomes are as follows: type 2 diabetes, glucose, HbA1c, insulin, lipid profile (LDL-cholesterol, HDL-cholesterol, triglycerides and apolipoprotein B), systolic blood pressure, diastolic blood pressure, and body mass index (BMI), which are well-established risk factors for CVD in clinical practice, or recently identified to be related to CVD in MR, such as apolipoprotein B [30, 31]

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A 2021 review published in Nutrients found that GLP-1 receptor agonist use was associated with reduced dietary intake of multiple micronutrients including B12, particularly in patients following calorie-restricted eating patterns, supporting the rationale for monitoring B12 status during treatment even in patients without pre-existing deficiency risk factors