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The high-MW fractions form a transient occlusive layer on the surface during recovery, holding water and reducing transepidermal water loss in the 24-to-48-hour post-procedure window where the barrier is briefly compromised

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10,12 Considering that AP2 is expressed in PGCs from E7.5 to E12.5, a period encompassing the entire germ cell migration period, our work supports the notion that AP2 is not only important for PGC specification but also critical for the maintenance of germ cell fate in migrating PGCs