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In a study with more than 6,000 people participating in one of two weight loss programs, those on a 500 calorie per day diet for three months, followed by nine months of weight maintenance, were three times more likely to need hospitalization for symptomatic gallstones or cholecystectomy for gallstones than those who started with a 1,2001,500 calorie per day diet

Because GLP-1s delay gastric emptying, they can increase residual gastric content raising the risk of pulmonary aspiration of gastric contents at induction and throughout an anesthetic even if a patient has been appropriately adherent to current NPO guidelines