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Possible Effects on Skin Pigmentation Melanin is a pigment that gives darkness to our skin, hair, and eyes as they heavily depend on the concentration of melanin

Key secondary endpoints included non-inferiority of tirzepatide (5 mg) compared to insulin degludec in HbA1c reduction, superiority of all tirzepatide doses over insulin degludec in HbA1c reduction and weight loss, and the proportion of participants achieving an HbA1c level below 7.0% at week 52

10.1038/clpt.1981.154 63 NauckM

Only the combination delivered all three together: HbA1c reduction, insulin sensitivity improvement, and cardiorespiratory fitness gains