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For GLP-1, the review confirmed insulinotropic effects on -cells during hyperglycaemia, glucagonostatic effects on -cells during hyperglycaemia (indirect, via somatostatin and insulin), gastric emptying delay, CNS appetite suppression, and indirect promotion of lipolysis via increased sympathetic activity
The liver plays a crucial role in metabolic homeostasis and influences nervous system function by regulating glucose, lipid, and cholesterol metabolism, as well as oxidative stress and inflammation [4, 5]
Thus, a human albumin variant resistant to enzymatic cleavage by CPA could not be obtained through L585 engineering without compromising FcRn binding
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