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This biomechanical loading accelerates the physical erosion of cartilage, leading to the frustration of the weight-pain cycle
Energy economics of muscle and fat during weight loss Different tissues have different metabolic demands
Furthermore, based on preclinical evidence suggesting that muscle-derived IL-6 may enhance postprandial GLP-1 secretion [90], it has been proposed that GLP-1RAs could modulate metabolic and inflammatory processes through this pathway [39]
doi:10.1038/s41598-020-80045-2
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