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Senolytic agents include natural compounds such as quercetin 13 or fisetin 14 , -galactosidase-activated nanoparticles and prodrugs 15,16,17 or compounds that target different vulnerabilities of senescent cells, such as HSP90 inhibitors 18 , cardiac glycosides 19,20 or NMT inhibitors 21
The therapy may take at least three months of daily treatment to be effective
Oct 24 2005;165(19):2214-2220
J Biol Chem 283(21):1458114589
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