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A plausible explanation is that hemin exists as a more chemically and conformationally heterogeneous ensemble: its axial chloride ligand can be readily exchanged for water/hydroxide, and the variability in central iron coordination and redox chemistry may hinder the formation of a stable, membrane-associated stacked hemin population 80
The FDA's Category 2 designation means the substance may present significant safety risks when used in compounding and is prohibited in compounded medications pending further evaluation
326 ( Pt 1) : p
One could speculate that a key treatment strategy for progressive MS could involve targeting CNS-resident B cells, not aiming to suppress their traditional immunological (mis)behavior, but instead to quell a yet-to-be-discovered unconventional action, possibly related to secretion of an MS-specific myelin toxin into the CSF
