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The most common side effects of GLP-1s may include: nausea, diarrhea, vomiting, constipation, stomach (abdomen) pain, headache, tiredness (fatigue), upset stomach, dizziness, feeling bloated, belching, gas, stomach flu, and heartburn

Several mechanisms may contribute to feelings of fatigue , including: Reduced caloric intake due to appetite suppression Gastrointestinal side effects affecting food and fluid intake Changes in blood glucose regulation Adjustment period as the body adapts to metabolic changes Dehydration from nausea or reduced fluid intake It is important to distinguish between normal tiredness during weight loss and fatigue that may indicate an underlying medical concern

Weight loss was accompanied by improvements in cardiometabolic risk factors including fasting glucose, insulin levels, lipid profiles, and blood pressure

Eng set about studying the Gila monster's venom and discovered a compound that had never been identified, one he dubbed exendin-4