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The experiment proved that the particle size distribution of CTB was uniform and stable both in vivo and in vitro , and CTB could be actively internalized in RTEC cells through macroprotein receptor-mediated endocytosis

In addition, the membrane susceptibility to ferroptotic damage is modulated by its lipidomic composition, with phospholipids enriched in PUFAs, particularly arachidonic acid (AA) and adrenic acid (AdA), being especially prone to peroxidation, thereby rendering membrane vulnerability to ferroptosis (24)

The amounts of total reduced and oxidized glutathione were quantified using a modified Tietze method by Adams ( Safety Measurements Any adverse event during the course of the study was monitored and reported to the study staff at week 6 (visit 5) or week 12 (visit 8) in the clinic or directly to the principal investigator throughout the study

High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinsons disease