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Mechanism of Action (Research Context) Pre-clinical research in lab models shows that BPC-157 modulates angiogenic growth factors and nitric oxide pathways, whereas TB-500 has an effect on the regulation of actin binding protein and cellular migration

*Correspondence: Yaqi Zeng [email protected] These authors have contributed equally to this work ORCID: Zhehong Shen orcid.org/0009-0002-0978-9127 Xiaotian Liu orcid.org/0009-0002-6508-720X Jun Meng orcid.org/0009-0004-4211-0870 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Visceral fat around organs and subcutaneous fat in specific areas may respond differently to various peptides

In short, DPP-4 removes two N-terminal amino acids from natural peptides positioned in the penultimate (S 1 ) site, such as proline or alanine, thus inactivating GLP-1 and GIP