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casei Shirota is the dominant thiol/disulphide redox system and the trxA1 trxA2 & trxB mutants of the strain have severely damaged growth rate which is restored after addition of glutathione in the medium [35]

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47 Taken together, these data suggest the reduced GSH/GSSG antioxidant capacity is insufficient to counter excessive OH production, and that unopposed OH can reach the nucleus to create the oxidative DNA adduct, 8-oxo-dG