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Approximately 85% of a therapeutic dose undergoes phase II conjugation to sulfated and glucuronidated metabolites that are renally eliminated
19 The EQ-5D utilities were subsequently regressed on polynomial BMI terms (linear, quadratic, and cubic), while adjusting for demographic and socioeconomic characteristics, lifestyle behaviors, and obesity-related comorbidities
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Constipation and insomnia scores increased at one month and decreased by three months, while pain scores significantly decreased across all three post-initiation time points (Figure 1)
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