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CSF fraction within the voxel ranged from 7 to 25% (mean 17%, 4.9% s.d.)
Cells contain glutathione in both reduced (GSH) and oxidised (GSSG) forms, whose balance is crucial for maintaining cellular redox potential 9
Accordingly, molecules with a good affinity and selectivity for these receptors/transporters can be explored as brain-targeting agents
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The proposed pathway is restoration of pinealocyte function either by direct gene-regulatory effects on serotonin-N-acetyltransferase (AANAT) and related enzymes, or indirectly by reducing neuroendocrine stress signalling
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