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Types, natural sources and mechanism of action of antioxidants An AOX is a natural substance that provides protection to the living cell against oxidative damage and deleterious effects of ROS ( Enzymatic AOXs include glutathione (GSH) peroxidase, glutathione reductase, catalase (CAT) and superoxide dismutase (SOD) ( Table 1 summarizes the types, natural dietary sources and the mechanism(s) of action of AOXs
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Indeed, several studies have demonstrated that aberrant IGF signaling plays a critical role in the pathogenesis and progression of several types of cancer, including lung, breast, colon, prostate, ovary, pancreas, and thyroid ( Nevertheless, data coming from observational studies are still conflicting and inconclusive, since some authors observe an association between insulin therapy and increased cancer risk (Tseng, 2019
