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We thank Gong-Min Lin at Metabolomics Core Facility of Agricultural Biotechnology Research Center in Academia Sinica for the assistance of metabolomics analysis and 13 C metabolite tracing
We set realistic expectations up front and measure against your own baseline rather than a promised result
Of these trials, four compared DPP-4 inhibitors against placebo (SAVOR-TIMI 53, EXAMINE, TECOS, CARMELINA), eight compared GLP-1RA against placebo (ELIXA, LEADER, SUSTAIN-6, EXSCEL, HARMONY, REWIND, PIONEER 6, AMPLITUTE-O) and eleven compared SGLT-2 inhibitors against placebo (EMPA-REG, CANVAS, DECLARE, CREDENCE, DAPA-HF, DAPA CKD, VERTIS-CV, EMPEROR-R, SCORED, SOLOIST-WHF, EMPEROR-P)
The chemical identity of the active ingredient is the same in both cases
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