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We also demonstrated that ectopic expression of wild-type mTOR, constitutively activate S6K1, or downregulated 4E-BP1 partially prevented rotenone-induced neuronal apoptosis, suggesting that rotenone-induced neuronal loss in PD may be prevented by activating mTOR signalling 15

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If dietary protein intake is insufficient, particularly glycine and proline which are collagens primary building blocks, the anabolic signaling has limited raw material to work with

There's also an initial adjustment period where detox signs can show, like changes in body odour, but those usually settle down