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This is noteworthy as (1) many biologically active peptides contain an -helix (a large fraction of PPIs involve an -helix) and (2) those helix portions could potentially be replaced or partially replaced by oligoureas with minimal effect on the binding while improving the proteolytic resistance of the peptide
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The term GLP-3 is often used online because the medication acts through three metabolic pathways, although triple agonist is the more accurate scientific description
doi: 10.1056/NEJMoa1603827 21 UngerJAllisonDCKaltoftMLakkoleKPandaJKRameshCet al
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