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however, when it is overexpressed it can contribute to pathogenic manifestations
The enzyme-catalyzed reverse reaction between GSSG or GSSR and reduced roGFP2 releases roGFP2(SSG) which can instantaneously react via a nonenzymatic shortcut yielding GSH and roGFP2(S 2 ) (Fig
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Another epigenetic regulator of interest is JMJD3 (also known as KDM6B), a histone H3K27 demethylase that plays crucial roles in both vascular and cancer biology
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