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Connecting those anecdotal accounts with the fact that there are GLP-1 receptors in the brain in regions that modulate reward processing, and therefore might affect cravings, Al-Aly and his collaborators investigated whether GLP-1s could treat all substance use disorders
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When appetite decreases and eating patterns change, some patients experience shifts in dopamine and serotonin signalingnot because the drug directly alters those neurotransmitters, but because eating behavior itself influences mood regulation
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